Immunogenicity Thresholds for Peptide Impurities Research

Oak Ridge Institute for Science and Education (ORISE) offers a research fellowship with the U.S. FDA CDER at White Oak, MD. The project focuses on establishing immunogenicity-based qualification thresholds for peptide and protein impurities, with emphasis on HLA-restricted T-cell responses and anti-drug antibodies. The fellow will gain hands-on experience in proteomics, MAAPs assays, and advanced analytics within a multi-disciplinary team, under an experienced mentor.