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Post-doctoral Research Fellow - Drug Discovery, Molecular Biology, Biochemistry

mgh institute of health professionsEast Boston, MA

3 days ago

Occupations

Medical Scientists, Except EpidemiologistsMolecular and Cellular BiologistsBiochemists and Biophysicists

Industries

Research and Development in BiotechnologyResearch and Development in the Physical, Engineering, and Life SciencesColleges, Universities, and Professional Schools
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About the role

Postdoctoral Fellow – Drug Discovery, Molecular Biology & Biochemistry The Shalhout Lab is recruiting a highly motivated postdoctoral fellow with expertise in small molecule drug discovery, molecular biology, biochemistry, and/or chemistry. Our group is developing innovative approaches to treat cancers by combining cutting-edge experimental biology with computational biology. We are seeking candidates with strong wet-lab skills who are excited to design, execute, and interpret experiments that drive therapeutic discovery.
Essential Functions:
  • Design and perform biophysical and biochemical assays, including protein purification, binding/interaction studies, cell reporter assays, and enzymatic assays. Purify and characterize proteins for structural and functional studies.
  • Design and perform protein–protein and protein–ligand interactions (e.g., SPR, ITC, pull-downs, FRET).Conduct cell-based functional assays such as reporter assays, qPCR, and molecular characterization of signaling pathways.
  • Carry out molecular biology techniques, including cloning, mutagenesis, and protein expression. Perform mutagenesis and structure–function studies to map binding sites and mechanisms of action.
  • Support hit validation and lead optimization through iterative testing of small molecules.
  • Collaborate with medicinal chemistry and computational teams to prioritize candidates and refine drug design.
  • Basic understanding of biostatistics
  • Analyze and interpret experimental data, present findings in lab meetings, publications, and conferences.
  • Collaborate with team members on projects linking experimental data to translational cancer research
Education and Experience: MD or PhD in a relevant field (Molecular Biology, Biochemistry, Biophysics, Cancer Biology, or related discipline) with a strong track record of peer-reviewed publications in areas such as drug discovery, small-molecule therapeutics, or translational oncology research.
Remote Type: Onsite
Work Location: 20 Staniford Street
Scheduled Weekly Hours: 40 Employee Type: Regular Work Shift: Day (United States of America)
EEO Statement: 5110 Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

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JOB OVERVIEW

Experience level

Lead

Location

East Boston, MA

Occupation

Medical Scientists, Except Epidemiologists

Industry

Research and Development in Biotechnology

Posted

3 days ago

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